Download e-book for iPad: Drug Absorption Studies: In Situ, in Vitro and in Silico by Carsten Ehrhardt,Kwang-Jin Kim

By Carsten Ehrhardt,Kwang-Jin Kim

ISBN-10: 0387749004

ISBN-13: 9780387749006

ISBN-10: 8184893876

ISBN-13: 9788184893878

within the final 15 years, a large number of telephone- or tissue-based in vitro versions were brought into the biopharmaceutics enviornment. those types mimic the several organic limitations drug has to beat to eventually achieve its objective organ/cell/receptor. those in vitro types were discovered very invaluable in not just characterising the permeability behaviour of substances molecules in epithelial and endothelial tissues, but additionally learning drug supply structures for enhanced supply and stronger absorption. in comparison to the complicated in vivo scenario, in vitro types supply a quick, handy process with fee merits such a lot of instances. most significantly, they are often standardised and automatised to be acceptable to the high-throughput screening. beginning on the molecular point of stories, carrying on with with phone monolayer types (both basic and mobile strains) and in situ innovations as a last checking out structure, the booklet offers a realistic method of modern in vitro options for drug absorption stories. moreover, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory matters are lined, giving a entire evaluate of accessible types and methods. additionally, an appendix comprised with a few sensible protocols is to be had on-line, up-to-date as wanted, may still end up very worthwhile to use the suggestions on to the benchside.

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Drug Absorption Studies: In Situ, in Vitro and in Silico Models: VII (Biotechnology: Pharmaceutical Aspects) by Carsten Ehrhardt,Kwang-Jin Kim

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