Ulo Langel's Cell-Penetrating Peptides: Processes and Applications PDF

By Ulo Langel

ISBN-10: 0849311411

ISBN-13: 9780849311413

one of many significant issues of drug supply is the lack of huge hydrophilic compounds to go through the lipid membrane of the telephone, therefore making medications corresponding to polypeptides and oligonucleotides of constrained healing worth. till lately, the delivery of such molecules into the cytoplasmic and nuclear cubicles of residing cells appeared a distant target. for this reason, the invention that peptides derived from the HIV Tat protein and homeodomain of the Antennapedia transcription issue (penetratin) can translocate around the plasma membrane of dwell cells has spread out fascinating new percentages in biomedical research.

This booklet fills the necessity for a accomplished replace of the study bearing on those really expert peptides, referred to as cell-penetrating peptides (CPPs), to which the drug molecule can connect and go through the cellphone membrane. Divided into 3 elements, Cell-Penetrating Peptides: approaches and purposes covers periods of cell-penetrating peptides; mechanisms of phone penetration, interactions of cell-penetrating peptides with plasma membranes, and lipid types; and purposes of cell-penetrating peptides. those divisions disguise all details from simple biochemistry to scientific program, together with a transparent description of the final ideas for mobile uptake of the delivery peptides. The assessment of labor during this sector will bring about higher designed novel shipping peptides to accomplish the extra winning software of CPPs in learn and therapy.

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Cell-Penetrating Peptides: Processes and Applications (Pharmacology and Toxicology: Basic and Clinical Aspects) by Ulo Langel

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