Anticarbohydrate Antibodies: From Molecular Basis to - download pdf or read online

By Paul Kosma,Sven Müller-Loennies

ISBN-10: 3709108691

ISBN-13: 9783709108697

ISBN-10: 3709148359

ISBN-13: 9783709148358

Many pathogens and aberrant malignant cells show detailed carbohydrates on their floor representing beautiful goals for vaccine layout. massive development has lately been made within the identity of novel carbohydrate established vaccines and a multitude has reached medical part reviews. The luck of numerous authorized carbohydrate dependent vaccines opposed to bacterial pathogens resembling Haemophilus influenzae kind b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their nice strength. notwithstanding, the research of anti-carbohydrate antibodies is technically not easy and partially due to low affinities and promiscuous specificity they've got now not been medically exploited to complete capability. The learn of antibody specificities and identity of protecting carbohydrate epitopes lies on the center of profitable vaccine layout. as well as remedy, antibodies usually function diagnostic instruments in scientific and medical laboratories. during this atmosphere excessive affinity and delightful specificity are vital components for his or her winning use. “Anticarbohydrate Antibodies – from molecular foundation to medical program” compiles present wisdom at the immunological attractiveness of carbohydrates by way of the adaptive immune method from a molecular viewpoint delivering primary perception wanted for advancing clinically suitable diagnostics and healing purposes. in keeping with major growth within the fields of glycoimmunology and structural biology lately, the booklet comprehensively experiences the state of the art in defining the foremost components of carbohydrate acceptance via antibodies, the molecular mimicry of carbohydrate epitopes in addition to the molecular good points resulting in particular and secure binding modes. Backed-up by way of a mixture of recent applied sciences to clarify structural information of carbohydrate-antibody interactions, biomedically vital carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells were analyzed in in-depth stories written through famous specialists within the box. basic wisdom of those molecular mechanisms finally offers a rational foundation to enhance efficacy of carbohydrate-based vaccines and to additional refine diagnostic instruments in detection of pathogens and malignant cells.

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Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application by Paul Kosma,Sven Müller-Loennies

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